Why do mice squeak? Toward a better understanding of defensive vocalization

Ruat, Julia; Genewsky, Andreas J.; Heinz, Daniel E.; Kaltwasser, Sebastian F.; Canteras, Newton S.; Czisch, Michael; Chen, Alon; Wotjak, Carsten T.

doi:10.1016/j.isci.2022.104657

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Why do mice squeak? Toward a better understanding of defensive vocalization

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Ruat, Julia
RG Neuronal Plasticity, Dept. Stress Neurobiology and Neurogenetics, Max Planck Institute of Psychiatry, Max Planck Society;
Dept. Stress Neurobiology and Neurogenetics, Max Planck Institute of Psychiatry, Max Planck Society;
IMPRS Translational Psychiatry, Max Planck Institute of Psychiatry, Max Planck Society;

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Genewsky, Andreas J.
RG Neuronal Plasticity, Dept. Stress Neurobiology and Neurogenetics, Max Planck Institute of Psychiatry, Max Planck Society;

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Heinz, Daniel E.
RG Neuronal Plasticity, Dept. Stress Neurobiology and Neurogenetics, Max Planck Institute of Psychiatry, Max Planck Society;

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Kaltwasser, Sebastian F.
RG Neuronal Plasticity, Dept. Stress Neurobiology and Neurogenetics, Max Planck Institute of Psychiatry, Max Planck Society;

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Czisch, Michael
Dept. Stress Neurobiology and Neurogenetics, Max Planck Institute of Psychiatry, Max Planck Society;

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Chen, Alon
Dept. Stress Neurobiology and Neurogenetics, Max Planck Institute of Psychiatry, Max Planck Society;

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Wotjak, Carsten T.
RG Neuronal Plasticity, Dept. Stress Neurobiology and Neurogenetics, Max Planck Institute of Psychiatry, Max Planck Society;

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Zitation

Ruat, J., Genewsky, A. J., Heinz, D. E., Kaltwasser, S. F., Canteras, N. S., Czisch, M., et al. (2022). Why do mice squeak? Toward a better understanding of defensive vocalization. ISCIENCE, 25(7): 104657. doi:10.1016/j.isci.2022.104657.

Zitierlink: https://hdl.handle.net/21.11116/0000-000A-D79C-4

Zusammenfassung

Although mice mostly communicate in the ultrasonic range, they also emit audible calls. We demonstrate that mice selectively bred for high anxiety-related behavior (HAB) have a high disposition for emitting sonic calls when caught by the tail. The vocalization was unrelated to pain but sensitive to anxiolytics. As revealed by manganese-enhanced MRI, HAB mice displayed an increased tonic activity of the periaqueductal gray (PAG). Selective inhibition of the dorsolateral PAG not only reduced anxiety-like behavior but also completely abolished sonic vocalization. Calls were emitted at a fundamental frequency of 3.8 kHz, which falls into the hearing range of numerous predators. Indeed, playback of sonic vocalization attracted rats if associated with a stimulus mouse. If played back to HAB mice, sonic calls were repellent in the absence of a conspecific but attractive in their presence. Our data demonstrate that sonic vocalization attracts both predators and conspecifics depending on the context.