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Journal Article

Receptor-type guanylate cyclase is required for carbon dioxide sensation by Caenorhabditis elegans

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Zeller,  G
Department Molecular Biology, Max Planck Institute for Developmental Biology, Max Planck Society;

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Henz,  SR
Department Molecular Biology, Max Planck Institute for Developmental Biology, Max Planck Society;

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Citation

Hallem, E., Spencer, W., McWhirter, R., Zeller, G., Henz, S., Rätsch, G., et al. (2011). Receptor-type guanylate cyclase is required for carbon dioxide sensation by Caenorhabditis elegans. Proceedings of the National Academy of Sciences of the United States of America, 108(1), 254-259. doi:10.1073/pnas.1017354108.


Cite as: https://hdl.handle.net/21.11116/0000-000A-DA8C-3
Abstract
CO2 is both a critical regulator of animal physiology and an important sensory cue for many animals for host detection, food location, and mate finding. The free-living soil nematode Caenorhabditis elegans shows CO2 avoidance behavior, which requires a pair of ciliated sensory neurons, the BAG neurons. Using in vivo calcium imaging, we show that CO2 specifically activates the BAG neurons and that the CO2-sensing function of BAG neurons requires TAX-2/TAX-4 cyclic nucleotide-gated ion channels and the receptor-type guanylate cyclase GCY-9. Our results delineate a molecular pathway for CO2 sensing and suggest that activation of a receptor-type guanylate cyclase is an evolutionarily conserved mechanism by which animals detect environmental CO2.