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Journal Article

Separation of voltage- and ligand-gated calcium influx in locust neurons by optical imaging

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Oertner,  TG
Borst Group, Friedrich Miescher Laboratory, Max Planck Society;

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Single,  S
Borst Group, Friedrich Miescher Laboratory, Max Planck Society;

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Borst,  A
Borst Group, Friedrich Miescher Laboratory, Max Planck Society;

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Citation

Oertner, T., Single, S., & Borst, A. (1999). Separation of voltage- and ligand-gated calcium influx in locust neurons by optical imaging. Neuroscience Letters, 274(2), 95-98. doi:10.1016/s0304-3940(99)00694-1.


Cite as: https://hdl.handle.net/21.11116/0000-000A-DCDB-8
Abstract
Calcium ions can enter neurons through either ionotropic transmitter receptors or through voltage-gated calcium channels. Thus, an observed rise in intracellular calcium concentration upon synaptic stimulation can be due to either one of these mechanisms or to both of them. We analyzed the individual contribution of transmitter- and voltage-gated calcium entry in non-spiking somata, acutely dissociated from thoracic ganglia of the locust Locusta migratoria. By optically recording the calcium signal following different stimulation protocols, we isolated the voltage- and the transmitter-gated component and found that these components indeed summate to the total rise in calcium observed under control conditions. (C) 1999 Elsevier Science Ireland Ltd. All rights reserved.