English
 
Help Privacy Policy Disclaimer
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
Add to Basket
  Local TagsRelease HistoryDetailsSummary

Released
Journal Article

Dacapo, a cyclin-dependent kinase inhibitor, stops cell proliferation during Drosophila development

MPS-Authors
/persons/resource/persons277093

Lane,  ME
Lehner Group, Friedrich Miescher Laboratory, Max Planck Society;

/persons/resource/persons277095

Sauer,  K
Lehner Group, Friedrich Miescher Laboratory, Max Planck Society;

/persons/resource/persons277069

Lehner,  CF
Lehner Group, Friedrich Miescher Laboratory, Max Planck Society;

External Resource
No external resources are shared
Fulltext (restricted access)
There are currently no full texts shared for your IP range.
Fulltext (public)
There are no public fulltexts stored in PuRe
Supplementary Material (public)
There is no public supplementary material available
Citation

Lane, M., Sauer, K., Wallace, K., Jan, Y., Lehner, C., & Vaessin, H. (1996). Dacapo, a cyclin-dependent kinase inhibitor, stops cell proliferation during Drosophila development. Cell, 87(7), 1225-1235. doi:10.1016/s0092-8674(00)81818-8.


Cite as: https://hdl.handle.net/21.11116/0000-000A-DD5D-6
Abstract
Most cell types in multicellular eukaryotes exit from the mitotic cell cycle before terminal differentiation. We show that the dacapo gene is required to arrest the epidermal cell proliferation at the correct developmental stage during Drosophila embryogenesis. dacapo encodes an inhibitor of cyclin E/cdk2 complexes with similarity to the vertebrate Cip/Kip inhibitors. dacapo is transiently expressed beginning late in the G2 phase preceding the terminal division (mitosis 16). Mutants unable to express the inhibitor fail to arrest cell proliferation after mitosis 16 and progress through an extra division cycle. Conversely, premature dacapo expression in transgenic embryos results in a precocious G1 arrest.