Role of GW182 proteins and PABPC1 in the miRNA pathway: a sense of déjà vu

Tritschler, F; Huntzinger, E; Izaurralde, E

doi:10.1038/nrm2885

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Role of GW182 proteins and PABPC1 in the miRNA pathway: a sense of déjà vu

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Tritschler, F
Department Biochemistry, Max Planck Institute for Developmental Biology, Max Planck Society;

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Huntzinger, E
Department Biochemistry, Max Planck Institute for Developmental Biology, Max Planck Society;

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Izaurralde, E
Department Biochemistry, Max Planck Institute for Developmental Biology, Max Planck Society;

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Citation

Tritschler, F., Huntzinger, E., & Izaurralde, E. (2010). Role of GW182 proteins and PABPC1 in the miRNA pathway: a sense of déjà vu. Nature Reviews Molecular Cell Biology, 11(5), 379-384. doi:10.1038/nrm2885.

Cite as: https://hdl.handle.net/21.11116/0000-000A-E285-0

Abstract

GW182 proteins have emerged as key components of microRNA (miRNA) silencing complexes in animals. Although the precise molecular function of GW182 proteins is not fully understood, new findings indicate that they act as poly(A)-binding protein (PABP)-interacting proteins (PAIPs) that promote gene silencing, at least in part, by interfering with cytoplasmic PABP1 (PABPC1) function during translation and mRNA stabilization. This recent discovery paves the way for future studies of miRNA silencing mechanisms.