A genetic map of the animal-parasitic nematode Strongyloides ratti

Nemetschke, L; Eberhardt, AG; Viney, ME; Streit, A

doi:10.1016/j.molbiopara.2009.10.008

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A genetic map of the animal-parasitic nematode Strongyloides ratti

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Nemetschke, L
Department Integrative Evolutionary Biology, Max Planck Institute for Developmental Biology, Max Planck Society;
Parasitic Nematode Group, Department Integrative Evolutionary Biology, Max Planck Institute for Developmental Biology, Max Planck Society;

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Eberhardt, AG
Department Integrative Evolutionary Biology, Max Planck Institute for Developmental Biology, Max Planck Society;
Parasitic Nematode Group, Department Integrative Evolutionary Biology, Max Planck Institute for Developmental Biology, Max Planck Society;

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Streit, A
Department Integrative Evolutionary Biology, Max Planck Institute for Developmental Biology, Max Planck Society;
Parasitic Nematode Group, Department Integrative Evolutionary Biology, Max Planck Institute for Developmental Biology, Max Planck Society;

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引用

Nemetschke, L., Eberhardt, A., Viney, M., & Streit, A. (2010). A genetic map of the animal-parasitic nematode Strongyloides ratti. Molecular and Biochemical Parasitology, 169(2), 124-127. doi:10.1016/j.molbiopara.2009.10.008.

引用: https://hdl.handle.net/21.11116/0000-000A-E2CF-E

要旨

Classical genetic approaches are rarely used with metazoan endo-parasites, largely because the adult stages are usually hidden within hosts, making controlled crosses difficult. The nematode Strongyloides ratti is a parasite of the small intestine of rats, and is a relative of the parasite of humans S. stercoralis. The life-cycle of Strongyloides spp. has a facultative free-living adult generation. Here we describe procedures for genetic mapping, and a genetic map, for S. ratti. This is, as far as we are aware, the first genetic map of an animal parasitic nematode. This significantly improves the usefulness of S. ratti as experimentally tractable system for parasitological investigations and for comparative studies with the model nematode Caenorhabditis elegans.