English
 
Help Privacy Policy Disclaimer
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT

Released

Journal Article

Ancient herpes simplex 1 genomes reveal recent viral structure in Eurasia

MPS-Authors
/persons/resource/persons72801

Krause,  Johannes       
Archaeogenetics, Max Planck Institute for the Science of Human History, Max Planck Society;
Department of Archaeogenetics, Max Planck Institute for Evolutionary Anthropology, Max Planck Society;

/persons/resource/persons179620

Herbig,  Alexander       
Archaeogenetics, Max Planck Institute for the Science of Human History, Max Planck Society;

External Resource
No external resources are shared
Fulltext (restricted access)
There are currently no full texts shared for your IP range.
Fulltext (public)

Guellil_Ancient_SciAdvan_2022.pdf
(Publisher version), 4MB

Supplementary Material (public)

Guellil_Ancient_SciAdvan_Suppl1_2022.pdf
(Supplementary material), 3MB

Guellil_Ancient_SciAdvan_Suppl2_2022.zip
(Supplementary material), 2MB

Citation

Guellil, M., van Dorp, L., Inskip, S. A., Dittmar, J. M., Saag, L., Tambets, K., et al. (2022). Ancient herpes simplex 1 genomes reveal recent viral structure in Eurasia. Science Advances, 8(30). doi:10.1126/sciadv.abo443.


Cite as: https://hdl.handle.net/21.11116/0000-000A-E71F-0
Abstract
Human herpes simplex virus 1 (HSV-1), a life-long infection spread by oral contact, today infects a majority of adults globally1, yet no ancient HSV-1 genomes have yet been published. Phylogeographic clustering of sampled diversity into European, pan-Eurasian, and African groups2, 3 has suggested that the virus co-diverged with anatomically modern humans migrating out of Africa4, although a much younger origin has also been proposed5. The lack of ancient HSV-1 genomes, high rates of recombination, and high mobility of humans in the modern era have impeded the understanding of HSV-1’s evolutionary history. Here we present three full ancient European HSV-1 genomes and one partial genome, dating to between the 3rd and 17th century CE, sequenced to up to 9.5× with paired human genomes up to 10.16×. These HSV-1 strains fall within modern Eurasian diversity. We estimate a mean mutation rate of 7.6 × 10-7