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Journal Article

Synthetic approaches to break the chemical shift degeneracy of glycans

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Dal Colle,  Marlene
Martina Delbianco, Biomolekulare Systeme, Max Planck Institute of Colloids and Interfaces, Max Planck Society;

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Fittolani,  Giulio
Martina Delbianco, Biomolekulare Systeme, Max Planck Institute of Colloids and Interfaces, Max Planck Society;

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Delbianco,  Martina
Martina Delbianco, Biomolekulare Systeme, Max Planck Institute of Colloids and Interfaces, Max Planck Society;

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Citation

Dal Colle, M., Fittolani, G., & Delbianco, M. (2022). Synthetic approaches to break the chemical shift degeneracy of glycans. Chembiochem, 23(24): e202200416. doi:10.1002/cbic.202200416.


Cite as: https://hdl.handle.net/21.11116/0000-000A-EB99-1
Abstract
NMR spectroscopy is the leading technique for determining glycans’ three-dimensional structure and dynamic in solution as well as a fundamental tool to study protein-glycan interactions. To overcome the severe chemical shift degeneracy of these compounds, synthetic probes carrying NMR-active nuclei (e.g., 13 C or 19 F) or lanthanide tags have been proposed. These elegant strategies permitted to simplify the complex NMR analysis of unlabeled analogues, shining light on glycans’ conformational aspects and interaction with proteins. Here, we highlight some key achievements in the synthesis of specifically labeled glycan probes and their contribution towards the fundamental understanding of glycans.