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Abstract

Background: The aim of this study was to evaluate the reproducibility and clinical value of the novel single-shot T1 mapping
method for rapid and accurate multi-slice coverage of the whole brain, described by Wang et al. 2015.

Methods: At a field strength of 3 Tesla, T1 mappings of 139 patients (51 of them without pathologic findings) and two repeats of
five volunteers were performed at 0.5 mm in-plane resolution. Mean T1 values were determined in 18 manually segmented
regions-of-interest without pathologic findings. Reproducibility of the repeated scans was calculated using mean coefficient of
variations. Pathologies were grouped and separately evaluated.

Results: The mean age of the cohort was 49 (range 1–95 years). T1 relaxation times for ordinary brain and pathologies were in
accordance with the literature values. Intra- and inter-subject reproducibility was excellent, and mean coefficient of variations
were 2.4% and 3.8%, respectively.

Discussion: The novel rapid T1 mapping method is a reliable magnetic resonance imaging technique for identifying and
quantifying normal brain structures and may thus serve as a basis for assessing pathologies. The fast and parallel online
calculation enables a comfortable use in everyday clinical practice. We see a possible clinical value in a large spectrum of
diseases, which should be investigated in further studies.