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Journal Article

Molecular diversity and evolution of neuron types in the amniote brain

MPS-Authors

Hain ,  David
Neural systems Department, Max Planck Institute for Brain Research, Max Planck Society;
Faculty of Biological Sciences, Goethe University, Frankfurt am Main, Germany.;

Gallego-Flores ,  Tatiana
Neural systems Department, Max Planck Institute for Brain Research, Max Planck Society;
Faculty of Biological Sciences, Goethe University, Frankfurt am Main, Germany.;

Klinkmann,  Michaela
Neural systems Department, Max Planck Institute for Brain Research, Max Planck Society;

Macias,  Angeles
Neural systems Department, Max Planck Institute for Brain Research, Max Planck Society;

Ciirdaeva,  Elena
Neural systems Department, Max Planck Institute for Brain Research, Max Planck Society;

Arends,  Anja
Neural systems Department, Max Planck Institute for Brain Research, Max Planck Society;

Thum,  Christina
Neural systems Department, Max Planck Institute for Brain Research, Max Planck Society;

Tushev,  Georgi
Neural systems Department, Max Planck Institute for Brain Research, Max Planck Society;

Kretschmer,  Friedrich
Neural systems Department, Max Planck Institute for Brain Research, Max Planck Society;

Tosches,  Maria Antonietta
Neural systems Department, Max Planck Institute for Brain Research, Max Planck Society;
Department of Biological Sciences, Columbia University, New York, NY, USA.;

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Laurent,  Gilles
Neural systems Department, Max Planck Institute for Brain Research, Max Planck Society;

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https://pubmed.ncbi.nlm.nih.gov/36048944/
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Citation

Hain, D., Gallego-Flores, T., Klinkmann, M., Macias, A., Ciirdaeva, E., Arends, A., et al. (2022). Molecular diversity and evolution of neuron types in the amniote brain. Science, 377(6610). doi:DOI: 10.1126/science.abp8202.


Cite as: https://hdl.handle.net/21.11116/0000-000A-F015-F
Abstract
The existence of evolutionarily conserved regions in the vertebrate brain is well established. The rules and constraints underlying the evolution of neuron types, however, remain poorly understood. To compare neuron types across brain regions and species, we generated a cell type atlas of the brain of a bearded dragon and compared it with mouse datasets. Conserved classes of neurons could be identified from the expression of hundreds of genes, including homeodomain-type transcription factors and genes involved in connectivity. Within these classes, however, there are both conserved and divergent neuron types, precluding a simple categorization of the brain into ancestral and novel areas. In the thalamus, neuronal diversification correlates with the evolution of the cortex, suggesting that developmental origin and circuit allocation are drivers of neuronal identity and evolution.