Computational methods for ultrastructural analysis of synaptic complexes

Lucic, Vladan

doi:10.1016/j.conb.2022.102611

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Computational methods for ultrastructural analysis of synaptic complexes

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Lucic, Vladan
Baumeister, Wolfgang / Molecular Structural Biology, Max Planck Institute of Biochemistry, Max Planck Society;

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Lucic, V. (2022). Computational methods for ultrastructural analysis of synaptic complexes. Current Opinion in Neurobiology, 76: 102611. doi:10.1016/j.conb.2022.102611.

Cite as: https://hdl.handle.net/21.11116/0000-000A-F16F-A

Abstract

Electron microscopy (EM) provided fundamental insights about the ultrastructure of neuronal synapses. The large amount of information present in the contemporary EM datasets pre-cludes a thorough assessment by visual inspection alone, thus requiring computational methods for the analysis of the data. Here, I review image processing software methods ranging from membrane tracing in large volume datasets to high res-olution structures of synaptic complexes. Particular attention is payed to molecular level analysis provided by recent cr yo -electron microscopy and tomography methods.