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Journal Article

Biomolecular condensates in epithelial junctions.

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Pombo-García,  Karina
Max Planck Institute for Molecular Cell Biology and Genetics, Max Planck Society;

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Honigmann,  Alf
Max Planck Institute for Molecular Cell Biology and Genetics, Max Planck Society;

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Citation

Sun, D., LuValle-Burke, I., Pombo-García, K., & Honigmann, A. (2022). Biomolecular condensates in epithelial junctions. Current opinion in cell biology, 77: 102089. doi:10.1016/j.ceb.2022.102089.


Cite as: https://hdl.handle.net/21.11116/0000-000B-0319-6
Abstract
Epithelial junctions are transmembrane protein complexes that regulate cell adhesion, cell polarity, tissue permeability, and tissue mechanics. Most junctional complexes contain membrane attached cytoplasmic plaques that regulate junction assembly and are composed of multivalent scaffold proteins. In this review, we discuss phase separation of multivalent proteins as a general process that drives assembly of many membrane-less cellular compartments. And we summarise recent evidence that phase separation of junctional scaffold proteins is involved in the assembly of tight junctions and focal adhesions.