Hepatobiliary tumor organoids for personalized medicine: a multicenter view on 
establishment, limitations, and future directions.

Tienderen, Gilles S van; Li, Ling; Broutier, Laura; Saito, Yoshimasa; Inacio, Patricia; Huch, Meritxell; Selaru, Florin M; Laan, Luc J W van der; Verstegen, Monique Ma

doi:10.1016/j.ccell.2022.02.001

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Hepatobiliary tumor organoids for personalized medicine: a multicenter view on establishment, limitations, and future directions.

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Huch, Meritxell
Max Planck Institute for Molecular Cell Biology and Genetics, Max Planck Society;

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Laan, Luc J W van der
Max Planck Institute for Molecular Cell Biology and Genetics, Max Planck Society;

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Citation

Tienderen, G. S. v., Li, L., Broutier, L., Saito, Y., Inacio, P., Huch, M., et al. (2022). Hepatobiliary tumor organoids for personalized medicine: a multicenter view on establishment, limitations, and future directions. Cancer cell, 40(3), 226-230. doi:10.1016/j.ccell.2022.02.001.

Cite as: https://hdl.handle.net/21.11116/0000-000B-0353-4

Abstract

Reliable establishment of tumor organoids is paramount to advance applications of organoid technology for personalized medicine. Here, we share our multi-center experience on initiation and tumorigenic confirmation of hepatobiliary cancer organoids. We discuss current concerns, propose potential solutions, and provide future perspectives for improvements in hepatobiliary cancer organoid establishment.