SARS-CoV-2 Infects Red Blood Cell Progenitors and Dysregulates Hemoglobin and 
Iron Metabolism.

Kronstein-Wiedemann, Romy; Stadtmüller, Marlena; Traikov, Sofia; Georgi, Mandy; Teichert, Madeleine; Yosef, Hesham; Wallenborn, Jan; Karl, Andreas; Schütze, Karin; Wagner, Michael; El-Armouche, A; Tonn, Torsten

doi:10.1007/s12015-021-10322-8

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SARS-CoV-2 Infects Red Blood Cell Progenitors and Dysregulates Hemoglobin and Iron Metabolism.

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Traikov, Sofia
Max Planck Institute for Molecular Cell Biology and Genetics, Max Planck Society;

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Citation

Kronstein-Wiedemann, R., Stadtmüller, M., Traikov, S., Georgi, M., Teichert, M., Yosef, H., et al. (2022). SARS-CoV-2 Infects Red Blood Cell Progenitors and Dysregulates Hemoglobin and Iron Metabolism. Stem cell reviews and reports, 18(5), 1809-1821. doi:10.1007/s12015-021-10322-8.

Cite as: https://hdl.handle.net/21.11116/0000-000B-037F-4

Abstract

SARS-CoV-2 infection causes acute respiratory distress, which may progress to multiorgan failure and death. Severe COVID-19 disease is accompanied by reduced erythrocyte turnover, low hemoglobin levels along with increased total bilirubin and ferritin serum concentrations. Moreover, expansion of erythroid progenitors in peripheral blood together with hypoxia, anemia, and coagulopathies highly correlates with severity and mortality. We demonstrate that SARS-CoV-2 directly infects erythroid precursor cells, impairs hemoglobin homeostasis and aggravates COVID-19 disease.