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Journal Article

Hox genes: realising the importance of realisators


Lohmann,  I
Department Molecular Biology, Max Planck Institute for Developmental Biology, Max Planck Society;

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Lohmann, I. (2006). Hox genes: realising the importance of realisators. Current Biology, 16(23), R988-R989. doi:10.1016/j.cub.2006.10.044.

Cite as: https://hdl.handle.net/21.11116/0000-000B-06B2-5
A recent study for the first time unravels a complete Hox regulatory network sufficient for the specification of a simple organ in Drosophila, linking Hox output to one specific group of executive genes, the realisators. As these genes have a direct effect on cellular functions and are required in most cell types, Hox genes may ultimately execute their function in controlling segmental fate by fine-tuning the spatial and temporal expression levels of these realisators.