High frequency stimulation of subthalamic nucleus synchronously modulates 
primary motor cortex and caudate putamen based on dopamine concentration and 
electrophysiology activities using microelectrode arrays in Parkinson’s disease 
rats

Zhang, Yu; Xu, Shengwei; Xiao, Guihua; Song, Yilin; Gao, Fei; Wang, Mixia; Zhao, Hongyan; Xing, Guogang; Cai, Xinxia

doi:10.1016/j.snb.2019.127126

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High frequency stimulation of subthalamic nucleus synchronously modulates primary motor cortex and caudate putamen based on dopamine concentration and electrophysiology activities using microelectrode arrays in Parkinson’s disease rats

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https://www.sciencedirect.com/science/article/pii/S0925400519313255?via%3Dihub
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Citation

Zhang, Y., Xu, S., Xiao, G., Song, Y., Gao, F., Wang, M., et al. (2019). High frequency stimulation of subthalamic nucleus synchronously modulates primary motor cortex and caudate putamen based on dopamine concentration and electrophysiology activities using microelectrode arrays in Parkinson’s disease rats. Sensors and Actuators B: Chemical, 301: 127126. doi:10.1016/j.snb.2019.127126.

Cite as: https://hdl.handle.net/21.11116/0000-000B-107F-5

Abstract

High-frequency stimulation of subthalamic nucleus (STN-HFS) is highly effective in alleviating motor symptoms in Parkinson’s disease (PD). However, there are few reports about the simultaneous changes of neural information, including neurotransmitter signal and neuro-electrophysiological signal (multiple brain regions), under the influence of STN-HFS. Here, a comprehensive system was established, while applying electrostimulation, modified microelectrode arrays were utilized to record dopamine concentration in caudate putamen (CPu) and to detect neuro-electrophysiological signal in primary motor cortex (M1) and CPu synchronously. Results show that rats with PD, dopamine level is significantly lower than that of normal rats; powers of spike trains in M1 and CPu are much higher than these of normal rats in low delta frequency range (0.3–1.5 Hz). Additionally, significant responses to STN-HFS were recorded. After STN-HFS, dopamine level dramatically increased more than 2-fold its pre-HFS; powers of M1 spike and CPu spike were suppressed in ∼1 Hz; Sequentially, neurotransmitter and electrophysiology activities gradually returned to stable, and recovered to PD-state. These observations revealed that the effects of STN-HFS were highly correlated with dopamine and electrophysiology activities in cortex-basal ganglia loop but last a brief duration, a theoretical basis that could be applied in closed-loop STN-HFS for long-term suppression of tremor.