English
 
Help Privacy Policy Disclaimer
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT

Released

Conference Paper

Different brain areas require different analysis models: fMRI observations in Parkinson's disease

MPS-Authors
/persons/resource/persons251108

Torrecuso,  Renzo
Methods and Development Unit Nuclear Magnetic Resonance, MPI for Human Cognitive and Brain Sciences, Max Planck Society;

/persons/resource/persons19872

Mueller,  Karsten
Methods and Development Unit Nuclear Magnetic Resonance, MPI for Human Cognitive and Brain Sciences, Max Planck Society;
Method and Development Group Neural Data Science and Statistical Computing, MPI for Human Cognitive and Brain Sciences, Max Planck Society;

/persons/resource/persons22883

Holiga,  Štefan
Methods and Development Unit Nuclear Magnetic Resonance, MPI for Human Cognitive and Brain Sciences, Max Planck Society;
Roche Pharma Research and Early Development, Roche Innovation Center;

/persons/resource/persons19981

Schroeter,  Matthias L.
Clinic for Cognitive Neurology, University Hospital Leipzig;
Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society;

/persons/resource/persons19864

Möller,  Harald E.
Methods and Development Unit Nuclear Magnetic Resonance, MPI for Human Cognitive and Brain Sciences, Max Planck Society;

External Resource
No external resources are shared
Fulltext (restricted access)
There are currently no full texts shared for your IP range.
Fulltext (public)

ViewSubmission (1).pdf
(Any fulltext), 597KB

Supplementary Material (public)
There is no public supplementary material available
Citation

Torrecuso, R., Mueller, K., Holiga, Š., Urgosik, D., Vymazal, J., Sieger, T., et al. (2022). Different brain areas require different analysis models: fMRI observations in Parkinson's disease. In Proceedings of the ISMRM 31st Annual Meeting & Exhibition.


Cite as: https://hdl.handle.net/21.11116/0000-000B-1222-A
Abstract
Foreseeing how specific brain areas respond in time to a stimulus can be a prerequisite for a successfully conceived fMRI experiment. We demonstrate that in medicated Parkinson’s disease patients, putamen's activation peaks around the onset of tapping but does not persist throughout the tapping block, whereas sustained activation is observed in the motor cortex. Consequently, in the widely used tapping paradigm “On vs. Off L-DOPA”, the drug effect remains undetected if statistical analysis apply a block design instead of an event-related one. Ignoring this information can lead to fallacious conclusions which suggests using different models to investigate different brain regions.