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Journal Article

The neuropeptide Pth2 modulates social behavior and anxiety in zebrafish

MPS-Authors

Anneser ,  Lukas
Synaptic Plasticity Department, Max Planck Institute for Brain Research, Max Planck Society;

Gemmer,  Anja
Synaptic Plasticity Department, Max Planck Institute for Brain Research, Max Planck Society;

Eilers,  Tim
Synaptic Plasticity Department, Max Planck Institute for Brain Research, Max Planck Society;

Alcantara,  Ivan C
Synaptic Plasticity Department, Max Planck Institute for Brain Research, Max Planck Society;

Loos,  Anett-Yvonn
Synaptic Plasticity Department, Max Planck Institute for Brain Research, Max Planck Society;

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Schuman,  Erin M.
Synaptic Plasticity Department, Max Planck Institute for Brain Research, Max Planck Society;

External Resource

https://pubmed.ncbi.nlm.nih.gov/35243231/
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Citation

Anneser, L., Gemmer, A., Eilers, T., Alcantara, I. C., Loos, A.-Y., Ryu, S., et al. (2022). The neuropeptide Pth2 modulates social behavior and anxiety in zebrafish. iScience, 25(3): 103868. doi:10.1016/j.isci.2022.103868.


Cite as: https://hdl.handle.net/21.11116/0000-000B-21CE-8
Abstract
Behavior is context-dependent and often modulated by an animal's internal state. In particular, different social contexts can alter anxiety levels and modulate social behavior. The vertebrate-specific neuropeptide parathyroid hormone 2 (pth2) is regulated by the presence of conspecifics in zebrafish. As its cognate receptor, the parathyroid hormone 2 receptor (pth2r), is widely expressed across the brain, we tested fish lacking the functional Pth2 peptide in several anxiety-related and social behavior paradigms. Here, we show that the propensity to react to sudden stimuli with an escape response was increased in pth2 -/- zebrafish, consistent with an elevated anxiety level. While overall social preference for conspecifics was maintained in pth2 -/- fish until the early juvenile stage, we found that both social preference and shoaling were altered later in development. The data presented suggest that the neuropeptide Pth2 modulates several conserved behaviors and may thus enable the animal to react appropriately in different social contexts.