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The attention-emotion interaction in healthy female participants on oral contraceptives during 1-week escitalopram intake

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Beinhölzl,  Nathalie       
Minerva Research Group EGG (Emotion & neuroimaGinG) Lab, MPI for Human Cognitive and Brain Sciences, Max Planck Society;
Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society;

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Molloy,  Eoin       
Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society;
University Clinic for Radiology and Nuclear Medicine, Otto von Guericke University Magdeburg, Germany;
German Center for Neurodegenerative Diseases, Magdeburg, Germany;

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Zsido,  Rachel       
Minerva Research Group EGG (Emotion & neuroimaGinG) Lab, MPI for Human Cognitive and Brain Sciences, Max Planck Society;
Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society;
Max Planck School of Cognition, Leipzig, Germany;

Piecha,  Fabian A.
Minerva Research Group EGG (Emotion & neuroimaGinG) Lab, MPI for Human Cognitive and Brain Sciences, Max Planck Society;
Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society;

Zheleva,  Gergana
Minerva Research Group EGG (Emotion & neuroimaGinG) Lab, MPI for Human Cognitive and Brain Sciences, Max Planck Society;
Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society;

Scharrer,  Ulrike
Minerva Research Group EGG (Emotion & neuroimaGinG) Lab, MPI for Human Cognitive and Brain Sciences, Max Planck Society;
Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society;

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Villringer,  Arno       
Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society;
Max Planck School of Cognition, Leipzig, Germany;
Clinic for Cognitive Neurology, University of Leipzig, Germany;
MindBrainBody Institute, Berlin School of Mind and Brain, Humboldt University Berlin, Germany;

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Sacher,  Julia       
Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society;
Max Planck School of Cognition, Leipzig, Germany;
Clinic for Cognitive Neurology, University of Leipzig, Germany;
Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, Helios Park Hospital Leipzig, Germany;

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Beinhoelzl_2022.pdf
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Citation

Beinhölzl, N., Molloy, E., Zsido, R., Richter, T., Piecha, F. A., Zheleva, G., et al. (2022). The attention-emotion interaction in healthy female participants on oral contraceptives during 1-week escitalopram intake. Frontiers in Neuroscience, 16: 809269. doi:10.3389/fnins.2022.809269.


Cite as: https://hdl.handle.net/21.11116/0000-000B-2D41-A
Abstract
Previous findings in healthy humans suggest that selective serotonin reuptake inhibitors (SSRIs) modulate emotional processing via earlier changes in attention. However, many previous studies have provided inconsistent findings. One possible reason for such inconsistencies is that these studies did not control for the influence of either sex or sex hormone fluctuations. To address this inconsistency, we administered 20 mg escitalopram or placebo for seven consecutive days in a randomized, double-blind, placebo-controlled design to sixty healthy female participants with a minimum of 3 months oral contraceptive (OC) intake. Participants performed a modified version of an emotional flanker task before drug administration, after a single dose, after 1 week of SSRI intake, and after a 1-month wash-out period. Supported by Bayesian analyses, our results do not suggest a modulatory effect of escitalopram on behavioral measures of early attentional-emotional interaction in female individuals with regular OC use. While the specific conditions of our task may be a contributing factor, it is also possible that a practice effect in a healthy sample may mask the effects of escitalopram on the attentional-emotional interplay. Consequently, 1 week of escitalopram administration may not modulate attention toward negative emotional distractors outside the focus of attention in healthy female participants taking OCs. While further research in naturally cycling females and patient samples is needed, our results represent a valuable contribution toward the preclinical investigation of antidepressant treatment.