Maternal exercise conveys protection against NAFLD in the offspring via hepatic 
metabolic programming

Bae-Gartz, Inga; Kasper, Philipp; Großmann, Nora; Breuer, Saida; Janoschek, Ruth; Kretschmer, Tobias; Appel, Sarah; Schmitz, Lisa; Vohlen, Christina; Quaas, Alexander; Schweiger, Michal R.; Grimm, Christina; Fischer, Axel; Ferrari, Nina; Graf, Christine; Frese, Christian K.; Lang, Sonja; Demir, Münevver; Schramm, Christoph; Fink, Gregor; Goeser, Tobias; Dötsch, Jörg; Hucklenbruch-Rother, Eva

doi:10.1038/s41598-020-72022-6

Item

ITEM ACTIONSEXPORT

Add to Basket

Local TagsRelease HistoryDetailsSummary

Released

Journal Article

Maternal exercise conveys protection against NAFLD in the offspring via hepatic metabolic programming

MPS-Authors

Frese, Christian K.
Max Planck Unit for the Science of Pathogens, Max Planck Society;

External Resource

No external resources are shared

Fulltext (restricted access)

There are currently no full texts shared for your IP range.

Fulltext (public)

There are no public fulltexts stored in PuRe

Supplementary Material (public)

There is no public supplementary material available

Citation

Bae-Gartz, I., Kasper, P., Großmann, N., Breuer, S., Janoschek, R., Kretschmer, T., et al. (2020). Maternal exercise conveys protection against NAFLD in the offspring via hepatic metabolic programming. Scientific Reports, 10(1), 15424. doi:10.1038/s41598-020-72022-6.

Cite as: https://hdl.handle.net/21.11116/0000-000B-34B5-E

Abstract

Abstract
Maternal exercise (ME) during pregnancy has been shown to improve metabolic health in offspring and confers protection against the development of non-alcoholic fatty liver disease (NAFLD). However, its underlying mechanism are still poorly understood, and it remains unclear whether protective effects on hepatic metabolism are already seen in the offspring early life. This study aimed at determining the effects of ME during pregnancy on offspring body composition and development of NAFLD while focusing on proteomic-based analysis of the hepatic energy metabolism during developmental organ programming in early life. Under an obesogenic high-fat diet (HFD), male offspring of exercised C57BL/6J-mouse dams were protected from body weight gain and NAFLD in adulthood (postnatal day (P) 112). This was associated with a significant activation of hepatic AMP-activated protein kinase (AMPK), peroxisome proliferator-activated receptor alpha (PPARα) and PPAR coactivator-1 alpha (PGC1α) signaling with reduced hepatic lipogenesis and increased hepatic β-oxidation at organ programming peak in early life (P21). Concomitant proteomic analysis revealed a characteristic hepatic expression pattern in offspring as a result of ME with the most prominent impact on Cholesterol 7 alpha-hydroxylase (CYP7A1). Thus, ME may offer protection against offspring HFD-induced NAFLD by shaping hepatic proteomics signature and metabolism in early life. The results highlight the potential of exercise during pregnancy for preventing the early origins of NAFLD.