A putative nuclear function for mammalian Staufen

Kiebler, MA; Jansen, R-P; Dahm, R; Macchi, P

doi:10.1016/j.tibs.2005.03.005

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A putative nuclear function for mammalian Staufen

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Kiebler, MA
Research Group Molecular Events at the Mammalian Synapse, Max Planck Institute for Developmental Biology, Max Planck Society;

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Dahm, R
Department Genetics, Max Planck Institute for Developmental Biology, Max Planck Society;

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Macchi, P
Research Group Molecular Events at the Mammalian Synapse, Max Planck Institute for Developmental Biology, Max Planck Society;

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Citation

Kiebler, M., Jansen, R.-P., Dahm, R., & Macchi, P. (2005). A putative nuclear function for mammalian Staufen. Trends in biochemical sciences, 30(5), 228-231. doi:10.1016/j.tibs.2005.03.005.

Cite as: https://hdl.handle.net/21.11116/0000-000B-37EB-F

Abstract

In addition to its role in rRNA processing and ribosome assembly, the nucleolus plays a part in the assembly of non-ribosomal ribonucleoprotein particles (RNPs) that are destined for cytoplasmic RNA delivery. Recent evidence indicates that mammalian Staufen2, a brain-specific RNA-binding protein involved in RNA localization, can--at least transiently--enter the nucleolus. Therefore, the assembly of Staufen2 into transport-competent RNPs might occur in the nucleus before their export into the cytoplasm. This could provide new insights into the mechanisms of subcellular RNA localization.