Good Ol' Fat: Links between Lipid Signaling and Longevity

Bustos, V.; Partridge, L.

doi:10.1016/j.tibs.2017.07.001

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Good Ol' Fat: Links between Lipid Signaling and Longevity

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Bustos, V.
Department Partridge - Biological Mechanisms of Ageing, Max Planck Institute for Biology of Ageing, Max Planck Society;

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Partridge, L.
Department Partridge - Biological Mechanisms of Ageing, Max Planck Institute for Biology of Ageing, Max Planck Society;

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https://www.ncbi.nlm.nih.gov/pubmed/28802547
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Citation

Bustos, V., & Partridge, L. (2017). Good Ol' Fat: Links between Lipid Signaling and Longevity. Trends Biochem Sci, 42(10), 812-823. doi:10.1016/j.tibs.2017.07.001.

Cite as: https://hdl.handle.net/21.11116/0000-000B-55D8-2

Abstract

Aging is the single greatest risk factor for the development of disease. Understanding the biological molecules and mechanisms that modulate aging is therefore critical for the development of health-maximizing interventions for older people. The effect of fats on longevity has traditionally been disregarded as purely detrimental. However, new studies are starting to uncover the possible beneficial effects of lipids working as signaling molecules on health and longevity. These studies highlight the complex links between aging and lipid signaling. In this review we summarize accumulating evidence that points to changes in lipid metabolism, and in particular lipid signaling, as an underlying mechanism for healthy aging.