Lipodystrophic laminopathy: Lamin A mutation relaxes chromatin architecture to 
impair adipogenesis

Elzeneini, E.; Wickström, S. A.

doi:10.1083/jcb.201707090

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Lipodystrophic laminopathy: Lamin A mutation relaxes chromatin architecture to impair adipogenesis

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Wickström, S. A.
Wickström – Skin Homeostasis and Ageing, Max Planck Research Groups, Max Planck Institute for Biology of Ageing, Max Planck Society;

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https://pubmed.ncbi.nlm.nih.gov/28811278/
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Citation

Elzeneini, E., & Wickström, S. A. (2017). Lipodystrophic laminopathy: Lamin A mutation relaxes chromatin architecture to impair adipogenesis. J Cell Biol, 216(9), 2607-2610. doi:10.1083/jcb.201707090.

Cite as: https://hdl.handle.net/21.11116/0000-000B-4F88-4

Abstract

The familial partial Dunnigan lipodystrophy, characterized by subcutaneous fat loss, is frequently caused by an R482W mutation in lamin A. In this issue, Oldenburg et al. (2017. J. Cell Biol. https://doi.org/10.1083/jcb.201701043) demonstrate that this mutation impairs the ability of lamin A to repress the anti-adipogenic miR-335, providing a potential molecular mechanism for the disease.