Lower serum levels of IL-1β and IL-6 cytokines in adolescents with anorexia 
nervosa and their association with gut microbiota in a longitudinal study

Specht, Hannah E.; Mannig, Nina; Belheouane, Meriem; Andreani, Nadia Andrea; Tenbrock, Klaus; Biemann, Ronald; Borucki, Katrin; Dahmen, Brigitte; Dempfle, Astrid; Baines, John F.; Herpertz-Dahlmann, Beate; Seitz, Jochen

doi:10.3389/fpsyt.2022.920665

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Lower serum levels of IL-1β and IL-6 cytokines in adolescents with anorexia nervosa and their association with gut microbiota in a longitudinal study

MPS-Authors

Specht, Hannah E.
Guest Group Evolutionary Medicine (Baines), Max Planck Institute for Evolutionary Biology, Max Planck Society;

Mannig, Nina
Guest Group Evolutionary Medicine (Baines), Max Planck Institute for Evolutionary Biology, Max Planck Society;

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Belheouane, Meriem
Guest Group Evolutionary Medicine (Baines), Max Planck Institute for Evolutionary Biology, Max Planck Society;

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Andreani, Nadia Andrea
Guest Group Evolutionary Medicine (Baines), Max Planck Institute for Evolutionary Biology, Max Planck Society;

Tenbrock, Klaus
Guest Group Evolutionary Medicine (Baines), Max Planck Institute for Evolutionary Biology, Max Planck Society;

Biemann, Ronald
Guest Group Evolutionary Medicine (Baines), Max Planck Institute for Evolutionary Biology, Max Planck Society;

Borucki, Katrin
Guest Group Evolutionary Medicine (Baines), Max Planck Institute for Evolutionary Biology, Max Planck Society;

Dahmen, Brigitte
Guest Group Evolutionary Medicine (Baines), Max Planck Institute for Evolutionary Biology, Max Planck Society;

Dempfle, Astrid
Guest Group Evolutionary Medicine (Baines), Max Planck Institute for Evolutionary Biology, Max Planck Society;

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Baines, John F.
Guest Group Evolutionary Medicine (Baines), Max Planck Institute for Evolutionary Biology, Max Planck Society;

Herpertz-Dahlmann, Beate
Guest Group Evolutionary Medicine (Baines), Max Planck Institute for Evolutionary Biology, Max Planck Society;

Seitz, Jochen
Guest Group Evolutionary Medicine (Baines), Max Planck Institute for Evolutionary Biology, Max Planck Society;

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Citation

Specht, H. E., Mannig, N., Belheouane, M., Andreani, N. A., Tenbrock, K., Biemann, R., et al. (2022). Lower serum levels of IL-1β and IL-6 cytokines in adolescents with anorexia nervosa and their association with gut microbiota in a longitudinal study. Frontiers in Psychiatry, 13: 920665. doi:10.3389/fpsyt.2022.920665.

Cite as: https://hdl.handle.net/21.11116/0000-000B-43F4-6

Abstract

Anorexia nervosa (AN) is an often chronic and debilitating psychiatric disease whose etiology is not completely understood. Recently, a potential role of inflammation has emerged in other psychiatric diseases, such as depression, PTSD and schizophrenia. The first results in adults with AN seemed to confirm a low-grade proinflammatory state until recent studies presented more differential findings. Studying adolescents with a shorter illness duration and fewer confounding factors might help elucidate the role of inflammation in the underlying pathophysiology of AN; however, the few available studies in adolescents remain ambiguous, and no longitudinal data are available in this age range.