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Journal Article

Retrospective real-world pilot data on transcranial pulse stimulation in mild to severe Alzheimer's patients

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Trenado,  Carlos       
Department of Music, Max Planck Institute for Empirical Aesthetics, Max Planck Society;

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Citation

Cont, C., Stute, N., Galli, A., Schulte, C., Logmin, K., Trenado, C., et al. (2022). Retrospective real-world pilot data on transcranial pulse stimulation in mild to severe Alzheimer's patients. Frontiers in Neurology, 13: 948204. doi:10.3389/fneur.2022.948204.


Cite as: https://hdl.handle.net/21.11116/0000-000B-46DC-F
Abstract
Transcranial pulse stimulation (TPS) is a non-invasive neuromodulation therapy that uses short, repetitive shockwaves through a neuro-navigated device. Current research suggests that these pulses lead to a wide range of vascular, metabolic, and neurotrophic changes. This relatively new CE-marked treatment provided first promising results in a clinical pilot study for improving cognition in mild-to-moderate Alzheimer's. Data from other centers is lacking, so here we analyzed safety and pilot real-world short-term results of TPS from the first center in Germany. To gain information about effects in different stages, patients with not only mild but also moderate-to-severe Alzheimer's were analyzed.