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Journal Article

Mapping the organization of axis of motion selective features in human area MT using high-field fMRI

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Zimmermann, J., Goebel, R., Martino, F. D., Moortele, P.-F.-v.-d., Feinberg, D., Adriany, G., et al. (2011). Mapping the organization of axis of motion selective features in human area MT using high-field fMRI. PLoS One, 6(12): e28716. doi:10.1371/journal.pone.0028716.

Cite as: https://hdl.handle.net/21.11116/0000-000B-47FB-B
Functional magnetic resonance imaging (fMRI) at high magnetic fields has made it possible to investigate the columnar organization of the human brain in vivo with high degrees of accuracy and sensitivity. Until now, these results have been limited to the organization principles of early visual cortex (V1). While the middle temporal area (MT) has been the first identified extra-striate visual area shown to exhibit a columnar organization in monkeys, evidence of MT's columnar response properties and topographic layout in humans has remained elusive. Research using various approaches suggests similar response properties as in monkeys but failed to provide direct evidence for direction or axis of motion selectivity in human area MT. By combining state of the art pulse sequence design, high spatial resolution in all three dimensions (0.8 mm isotropic), optimized coil design, ultrahigh field magnets (7 Tesla) and novel high resolution cortical grid sampling analysis tools, we provide the first direct evidence for large-scale axis of motion selective feature organization in human area MT closely matching predictions from topographic columnar-level simulations.