Localization matters in targeted protein degradation

Shah, Varun Jayeshkumar; Đikić, Ivan

doi:10.1016/j.chembiol.2022.09.006

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Localization matters in targeted protein degradation

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Đikić, Ivan
Institute of Biochemistry II, Faculty of Medicine, Goethe University, Frankfurt, Germany;
Buchmann Institute for Molecular Life Sciences, Goethe University, Frankfurt, Germany;
Max Planck Fellow Group ER remodelling Group, Prof. Ivan Đikić, Max Planck Institute of Biophysics, Max Planck Society;
Fraunhofer Institute for Molecular Biology and Applied Ecology (IME), Branch Translational Medicine and Pharmacology, Frankfurt, Germany;

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引用

Shah, V. J., & Đikić, I. (2022). Localization matters in targeted protein degradation. Cell Chemical Biology, 29(10), 1465-1466. doi:10.1016/j.chembiol.2022.09.006.

引用: https://hdl.handle.net/21.11116/0000-000B-528B-C

要旨

Many factors influence the efficiency of targeted protein degradation induced by proteolysis targeting chimeras (PROTACs). In this issue of Cell Chemical Biology, Simpson et al. (2022) highlight the impact of subcellular localization. Their study elucidates that the protein of interest exhibits different amenability to PROTAC-mediated degradation at different cellular compartments.