English
 
Help Privacy Policy Disclaimer
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
Add to Basket
  Local TagsRelease HistoryDetailsSummary

Released
Journal Article

Synthesis and biological applications of 2′,3′-dideoxynucleoside-5′-O-(α-thio)triphosphates

MPS-Authors
/persons/resource/persons282090

Auer,  M.
Emeritus Group Biophysics, Max Planck Institute for Medical Research, Max Planck Society;

/persons/resource/persons282098

Kriege,  C.
Department of Organic Chemistry, Max Planck Institute for Medical Research, Max Planck Society;

/persons/resource/persons282096

Gautel,  M.
Emeritus Group Biophysics, Max Planck Institute for Medical Research, Max Planck Society;

/persons/resource/persons274997

Weiß,  S.
Emeritus Group Biophysics, Max Planck Institute for Medical Research, Max Planck Society;

/persons/resource/persons93142

Goody,  R. S.
Emeritus Group Biophysics, Max Planck Institute for Medical Research, Max Planck Society;

External Resource

https://www.tandfonline.com/doi/abs/10.1080/07328318908054228
(Any fulltext)

https://www.tandfonline.com/doi/pdf/10.1080/07328318908054228?needAccess=true
(Any fulltext)

Fulltext (restricted access)
There are currently no full texts shared for your IP range.
Fulltext (public)
There are no public fulltexts stored in PuRe
Supplementary Material (public)
There is no public supplementary material available
Citation

Auer, M., Kriege, C., Gautel, M., Labeit, S., Sczakiel, G., Weiß, S., et al. (1989). Synthesis and biological applications of 2′,3′-dideoxynucleoside-5′-O-(α-thio)triphosphates. Nucleosides & Nucleotides, 8(5-6), 849-853. doi:10.1080/07328318908054228.


Cite as: https://hdl.handle.net/21.11116/0000-000B-5439-7
Abstract
Fast and efficient syntheses of 2′,3′-dideoxynucleoside-5′-O-(α-thio)triphosphates (α-S-ddNTP's) starting from 2′-deoxynucleosides are described. They have been used in a modified DNA-sequencing method and were tested as potential inhibitors of HIV-1 reverse transcriptase. An X-ray structure of 3′-deoxythymidine is presented and compared to other known 2′,3′-dideoxynucleoside structures.