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Complete genome sequence and analysis of Wolinella succinogenes

MPS-Authors
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Baar,  C
Genome Center, Max Planck Institute for Developmental Biology, Max Planck Society;

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Eppinger,  M
Genome Center, Max Planck Institute for Developmental Biology, Max Planck Society;

/persons/resource/persons84151

Raddatz,  G
Genome Center, Max Planck Institute for Developmental Biology, Max Planck Society;

/persons/resource/persons271710

Lanz,  C
Genome Center, Max Planck Institute for Developmental Biology, Max Planck Society;

/persons/resource/persons282446

Nandakumar,  R
Research Group Genomics and Signal Transduction, Max Planck Institute for Developmental Biology, Max Planck Society;

/persons/resource/persons282362

Rosinus,  A
Genome Center, Max Planck Institute for Developmental Biology, Max Planck Society;

/persons/resource/persons274207

Keller,  H
Research Group Genomics and Signal Transduction, Max Planck Institute for Developmental Biology, Max Planck Society;

/persons/resource/persons276094

Jagtap,  P
Research Group Genomics and Signal Transduction, Max Planck Institute for Developmental Biology, Max Planck Society;

/persons/resource/persons78680

Schuster,  SC
Research Group Genomics and Signal Transduction, Max Planck Institute for Developmental Biology, Max Planck Society;

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Citation

Baar, C., Eppinger, M., Raddatz, G., Simon, J., Lanz, C., Klimmek, O., et al. (2003). Complete genome sequence and analysis of Wolinella succinogenes. Proceedings of the National Academy of Sciences of the United States of America, 100(20), 11690-11695. doi:10.1073/pnas.1932838100.


Cite as: https://hdl.handle.net/21.11116/0000-000B-619D-7
Abstract
To understand the origin and emergence of pathogenic bacteria, knowledge of the genetic inventory from their nonpathogenic relatives is a prerequisite. Therefore, the 2.11-megabase genome sequence of Wolinella succinogenes, which is closely related to the pathogenic bacteria Helicobacter pylori and Campylobacter jejuni, was determined. Despite being considered nonpathogenic to its bovine host, W. succinogenes holds an extensive repertoire of genes homologous to known bacterial virulence factors. Many of these genes have been acquired by lateral gene transfer, because part of the virulence plasmid pVir and an N-linked glycosylation gene cluster were found to be syntenic between C. jejuni and genomic islands of W. succinogenes. In contrast to other host-adapted bacteria, W. succinogenes does harbor the highest density of bacterial sensor kinases found in any bacterial genome to date, together with an elaborate signaling circuitry of the GGDEF family of proteins. Because the analysis of the W. succinogenes genome also revealed genes related to soil- and plant-associated bacteria such as the nif genes, W. succinogenes may represent a member of the epsilon proteobacteria with a life cycle outside its host.