A role for maternal beta-catenin in early mesoderm induction in Xenopus

Schohl, A; Fagotto, F

doi:10.1093/emboj/cdg328

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A role for maternal beta-catenin in early mesoderm induction in Xenopus

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Schohl, A
Department Cell Biology, Max Planck Institute for Developmental Biology, Max Planck Society;

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Fagotto, F
Department Cell Biology, Max Planck Institute for Developmental Biology, Max Planck Society;

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Citation

Schohl, A., & Fagotto, F. (2003). A role for maternal beta-catenin in early mesoderm induction in Xenopus. EMBO Journal, 22(13), 3303-3313. doi:10.1093/emboj/cdg328.

Cite as: https://hdl.handle.net/21.11116/0000-000B-64D7-2

Abstract

Mesoderm formation results from an inducing process that requires maternal and zygotic FGF/MAPK and TGFbeta activities, while maternal activation of the Wnt/beta-catenin pathway determines the anterior-dorsal axis. Here, we show a new role of Wnt/beta-catenin signaling in mesoderm induction. We find that maternal beta-catenin signaling is not only active dorsally but also all around the equatorial region, coinciding with the prospective mesoderm. Maternal beta-catenin function is required both for expression of dorsal genes and for activation of MAPK and the mesodermal markers Xbra and eomesodermin. beta-catenin acts in a non- cell-autonomous manner upstream of zygotic FGF and nodal signals. The Wnt/beta-catenin activity in the equatorial region of the early embryo is the first example of a maternally provided mesoderm inducer restricted to the prospective mesoderm.