NompC TRP channel required for vertebrate sensory hair cell mechanotransduction

Sidi, S; Friedrich, RW; Nicolson, T

doi:10.1126/science.1084370

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NompC TRP channel required for vertebrate sensory hair cell mechanotransduction

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Sidi, S
Department Genetics, Max Planck Institute for Developmental Biology, Max Planck Society;

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Nicolson, T
Department Genetics, Max Planck Institute for Developmental Biology, Max Planck Society;

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引用

Sidi, S., Friedrich, R., & Nicolson, T. (2003). NompC TRP channel required for vertebrate sensory hair cell mechanotransduction. Science, 301(5629), 96-99. doi:10.1126/science.1084370.

引用: https://hdl.handle.net/21.11116/0000-000B-64E1-6

要旨

The senses of hearing and balance in vertebrates rely on the sensory hair cells (HCs) of the inner ear. The central element of the HC's transduction apparatus is a mechanically gated ion channel of unknown identity. Here we report that the zebrafish ortholog of Drosophila no mechanoreceptor potential C (nompC), which encodes a transient receptor potential (TRP) channel, is critical for HC mechanotransduction. In zebrafish larvae, nompC is selectively expressed in sensory HCs. Morpholino-mediated removal of nompC function eliminated transduction-dependent endocytosis and electrical responses in HCs, resulting in larval deafness and imbalance. These observations indicate that nompC encodes a vertebrate HC mechanotransduction channel.