The evolution of signalling pathways in animal development

Pires-daSilva, A; Sommer, RJ

doi:10.1038/nrg977

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The evolution of signalling pathways in animal development

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Pires-daSilva, A
Department Integrative Evolutionary Biology, Max Planck Institute for Developmental Biology, Max Planck Society;

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Sommer, RJ
Department Integrative Evolutionary Biology, Max Planck Institute for Developmental Biology, Max Planck Society;

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Pires-daSilva, A., & Sommer, R. (2003). The evolution of signalling pathways in animal development. Nature Reviews Genetics, 4(1), 39-49. doi:10.1038/nrg977.

Cite as: https://hdl.handle.net/21.11116/0000-000B-64F5-0

Abstract

Despite the bewildering number of cell types and patterns found in the animal kingdom, only a few signalling pathways are required to generate them. Most cell-cell interactions during embryonic development involve the Hedgehog, Wnt, transforming growth factor-beta, receptor tyrosine kinase, Notch, JAK/STAT and nuclear hormone pathways. Looking at how these pathways evolved might provide insights into how a few signalling pathways can generate so much cellular and morphological diversity during the development of individual organisms and the evolution of animal body plans.