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Separation of sister chromatids in mitosis requires the Drosophila pimples product, a protein degraded after the metaphase/anaphase transition

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Stratmann,  R
Lehner Group, Friedrich Miescher Laboratory, Max Planck Society;

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Lehner,  CF
Lehner Group, Friedrich Miescher Laboratory, Max Planck Society;

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Citation

Stratmann, R., & Lehner, C. (1996). Separation of sister chromatids in mitosis requires the Drosophila pimples product, a protein degraded after the metaphase/anaphase transition. Cell, 84(1), 25-35. doi:10.1016/s0092-8674(00)80990-3.


Cite as: https://hdl.handle.net/21.11116/0000-000B-66AD-0
Abstract
Mutations in the Drosophila genes pimples and three rows result in a defect of sister chromatid separation during mitosis. As a consequence, cytokinesis is also defective. However, cell cycle progression including the mitotic degradation of cyclins A and B is not blocked by the failure of sister chromatid separation, and as a result, metaphase chromosomes with twice the normal number of chromosome arms still connected in the centromeric region are observed in the following mitosis, pimples encodes a novel protein that is rapidly degraded in mitosis. Our observations suggest that Pimples and Three rows act during mitosis to release the cohesion between sister centromeres.