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Journal Article

Cyclin E controls S phase progression and its down-regulation during Drosophila embryogenesis is required for the arrest of cell proliferation

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Knoblich,  JA
Lehner Group, Friedrich Miescher Laboratory, Max Planck Society;

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Sauer,  K
Lehner Group, Friedrich Miescher Laboratory, Max Planck Society;

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Lehner,  CF
Lehner Group, Friedrich Miescher Laboratory, Max Planck Society;

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Citation

Knoblich, J., Sauer, K., Jones, L., Richardson, H., Saint, R., & Lehner, C. (1994). Cyclin E controls S phase progression and its down-regulation during Drosophila embryogenesis is required for the arrest of cell proliferation. Cell, 77(1), 107-120. doi:10.1016/0092-8674(94)90239-9.


Cite as: https://hdl.handle.net/21.11116/0000-000B-676A-B
Abstract
Most cells of the dorsal epidermis exit from the mitotic cycle after division 16 in Drosophila embryogenesis. This exit is dependent on the down-regulation of Drosophila cyclin E (DmcycE) during the final mitotic cycle. Ectopic expression of DmcycE after the final mitosis induces entry into S phase and reaccumulation of G2 cyclins and results in progression through a complete additional cell cycle. Conversely, analyses in DmcycE mutant embryos indicate that cyclin E is required for progression through S phase of the mitotic cycle. Moreover, endoreplication, which occurs in late wild-type embryos in the same pattern as DmcycE expression, is not observed in the mutant embryos. Therefore, Drosophila cyclin E, which forms a complex with the Dmcdc2c kinase, controls progression through S phase and its down-regulation limits embryonic proliferation.