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Tipping the balance toward longevity

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Antebi,  A.
Department Antebi - Molecular Genetics of Ageing, Max Planck Institute for Biology of Ageing, Max Planck Society;

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Citation

Antebi, A. (2004). Tipping the balance toward longevity. Dev Cell, 6(3), 315-6.


Cite as: https://hdl.handle.net/21.11116/0000-000B-71E6-2
Abstract
Genetic experiments in C. elegans suggested that SIR2, an NAD-dependent protein deacetylase, acts through FOXO/DAF-16 transcription factor to prolong life. Recent studies show that mammalian SIR2 deacetylates FOXO, and may maximize survival by tempering cell death and increasing stress resistance.