Steroid regulation of C. elegans diapause, developmental timing, and longevity

Antebi, A.

doi:10.1016/b978-0-12-396968-2.00007-5

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Steroid regulation of C. elegans diapause, developmental timing, and longevity

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Antebi, A.
Department Antebi - Molecular Genetics of Ageing, Max Planck Institute for Biology of Ageing, Max Planck Society;

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http://www.ncbi.nlm.nih.gov/pubmed/23962843
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Citation

Antebi, A. (2013). Steroid regulation of C. elegans diapause, developmental timing, and longevity. Curr Top Dev Biol, 105, 181-212. doi:10.1016/b978-0-12-396968-2.00007-5.

Cite as: https://hdl.handle.net/21.11116/0000-000B-B3FB-0

Abstract

Hormones play a critical role in driving major stage transitions and developmental timing events in many species. In the nematode C. elegans the steroid hormone receptor, DAF-12, works at the confluence of pathways regulating developmental timing, stage specification, and longevity. DAF-12 couples environmental and physiologic signals to life history regulation, and it is embedded in a rich architecture governing diverse processes. Here, we highlight the molecular insights, extraordinary circuitry, and signaling pathways governing life stage transitions in the worm and how they have yielded fundamental insights into steroid regulation of biological time.