Is energy deficiency good in moderation?

Freyer, C.; Larsson, N.G.

doi:10.1016/j.cell.2007.10.027

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Is energy deficiency good in moderation?

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Larsson, N.G.
Department Larsson - Mitochondrial Biology, Max Planck Institute for Biology of Ageing, Max Planck Society;

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Freyer, C., & Larsson, N. (2007). Is energy deficiency good in moderation? Cell, 131(3), 448-50. doi:10.1016/j.cell.2007.10.027.

Cite as: https://hdl.handle.net/21.11116/0000-000B-9D99-8

Abstract

In this issue, Pospisilik et al. (2007) demonstrate that a reduction in mitochondrial oxidative phosphorylation protects mice against obesity and diabetes. This finding suggests that the moderate deficiency in oxidative phosphorylation that is observed in peripheral tissues of insulin-resistant humans is not a causative factor in diabetes but may instead be a compensatory response.