AAA proteases: cellular machines for degrading membrane proteins

Langer, T.

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AAA proteases: cellular machines for degrading membrane proteins

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Langer, T.
Department Langer - Mitochondrial Proteostasis, Max Planck Institute for Biology of Ageing, Max Planck Society;

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https://www.ncbi.nlm.nih.gov/pubmed/10782097
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引用

Langer, T. (2000). AAA proteases: cellular machines for degrading membrane proteins. Trends Biochem Sci, 25(5), 247-51.

引用: https://hdl.handle.net/21.11116/0000-000B-7019-B

要旨

AAA proteases are a conserved class of ATP-dependent proteases that mediate the degradation of membrane proteins in bacteria, mitochondria and chloroplasts. They combine proteolytic and chaperone-like activities and thus form a membrane-integrated quality-control system. Inactivation of AAA proteases causes severe defects in various organisms, including neurodegeneration in humans. Proteolysis by AAA proteases is modulated by another membrane-protein complex that is composed of prohibitins in eukaryotic cells and related proteins in bacteria.