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Journal Article

Animal models for respiratory chain disease


Larsson,  N.G.
Department Larsson - Mitochondrial Biology, Max Planck Institute for Biology of Ageing, Max Planck Society;

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Larsson, N., & Rustin, P. (2001). Animal models for respiratory chain disease. Trends Mol Med, 7(12), 578-81.

Cite as: https://hdl.handle.net/21.11116/0000-000B-71C3-9
Elucidation of the pathogenesis in respiratory chain diseases is of great importance for developing specific treatments. The limitations inherent to the use of patient material make studies of human tissues often difficult and the mouse has therefore emerged as a suitable model organism for studies of respiratory chain diseases. In this review, we present an overview of the field and discuss in depth a few examples of animal models reproducing pathology of human disease with primary and secondary respiratory chain involvement.