Mitofusin 2 builds a bridge between ER and mitochondria

Merkwirth, C.; Langer, T.

doi:10.1016/j.cell.2008.12.005

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Mitofusin 2 builds a bridge between ER and mitochondria

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Langer, T.
Department Langer - Mitochondrial Proteostasis, Max Planck Institute for Biology of Ageing, Max Planck Society;

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https://www.ncbi.nlm.nih.gov/pubmed/19109886
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Citation

Merkwirth, C., & Langer, T. (2008). Mitofusin 2 builds a bridge between ER and mitochondria. Cell, 135(7), 1165-7. doi:10.1016/j.cell.2008.12.005.

Cite as: https://hdl.handle.net/21.11116/0000-000B-80FB-9

Abstract

Mutations in mitofusin 2 (MFN2), a dynamin-like GTPase required for mitochondrial fusion, cause the peripheral neuropathy Charcot-Marie-Tooth type 2A. In a recent report in Nature, de Brito and Scorrano (2008) demonstrate a new function of MFN2-tethering the endoplasmic reticulum and mitochondria to control the efficiency of mitochondrial uptake of Ca2+ ions.