MTERF3 regulates mitochondrial ribosome biogenesis in invertebrates and mammals

Wredenberg, A.; Lagouge, M.; Bratic, A.; Metodiev, M. D.; Spahr, H.; Mourier, A.; Freyer, C.; Ruzzenente, B.; Tain, L. S.; Grönke, S.; Baggio, F.; Kukat, C.; Kremmer, E.; Wibom, R.; Polosa, P. L.; Habermann, B.H.; Partridge, L.; Park, C. B.; Larsson, N.G.

doi:10.1371/journal.pgen.1003178

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MTERF3 regulates mitochondrial ribosome biogenesis in invertebrates and mammals

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Wredenberg, A.
Department Larsson - Mitochondrial Biology, Max Planck Institute for Biology of Ageing, Max Planck Society;

/persons/resource/persons129396

Lagouge, M.
Department Larsson - Mitochondrial Biology, Max Planck Institute for Biology of Ageing, Max Planck Society;

/persons/resource/persons129386

Bratic, A.
Department Larsson - Mitochondrial Biology, Max Planck Institute for Biology of Ageing, Max Planck Society;

/persons/resource/persons278397

Spahr, H.
Department Larsson - Mitochondrial Biology, Max Planck Institute for Biology of Ageing, Max Planck Society;

/persons/resource/persons129412

Mourier, A.
Department Larsson - Mitochondrial Biology, Max Planck Institute for Biology of Ageing, Max Planck Society;

/persons/resource/persons129436

Tain, L. S.
Department Partridge - Biological Mechanisms of Ageing, Max Planck Institute for Biology of Ageing, Max Planck Society;

/persons/resource/persons129428

Grönke, S.
Department Partridge - Biological Mechanisms of Ageing, Max Planck Institute for Biology of Ageing, Max Planck Society;

/persons/resource/persons129382

Baggio, F.
Department Larsson - Mitochondrial Biology, Max Planck Institute for Biology of Ageing, Max Planck Society;

/persons/resource/persons129360

Kukat, C.
Department Larsson - Mitochondrial Biology, Max Planck Institute for Biology of Ageing, Max Planck Society;

/persons/resource/persons129853

Habermann, B.H.
Bioinformatics, Core Facilities, Max Planck Institute for Biology of Ageing, Max Planck Society;

/persons/resource/persons129348

Partridge, L.
Department Partridge - Biological Mechanisms of Ageing, Max Planck Institute for Biology of Ageing, Max Planck Society;

/persons/resource/persons129342

Larsson, N.G.
Department Larsson - Mitochondrial Biology, Max Planck Institute for Biology of Ageing, Max Planck Society;

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http://www.ncbi.nlm.nih.gov/pubmed/23300484
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Citation

Wredenberg, A., Lagouge, M., Bratic, A., Metodiev, M. D., Spahr, H., Mourier, A., et al. (2013). MTERF3 regulates mitochondrial ribosome biogenesis in invertebrates and mammals. PLoS Genet, 9(1), e1003178. doi:10.1371/journal.pgen.1003178.

Cite as: https://hdl.handle.net/21.11116/0000-000B-68F5-C

Abstract

Regulation of mitochondrial DNA (mtDNA) expression is critical for the control of oxidative phosphorylation in response to physiological demand, and this regulation is often impaired in disease and aging. We have previously shown that mitochondrial transcription termination factor 3 (MTERF3) is a key regulator that represses mtDNA transcription in the mouse, but its molecular mode of action has remained elusive. Based on the hypothesis that key regulatory mechanisms for mtDNA expression are conserved in metazoans, we analyzed Mterf3 knockout and knockdown flies. We demonstrate here that decreased expression of MTERF3 not only leads to activation of mtDNA transcription, but also impairs assembly of the large mitochondrial ribosomal subunit. This novel function of MTERF3 in mitochondrial ribosomal biogenesis is conserved in the mouse, thus we identify a novel and unexpected role for MTERF3 in coordinating the crosstalk between transcription and translation for the regulation of mammalian mtDNA gene expression.