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Journal Article

The Drosophila gene torso encodes a putative receptor tyrosine kinase

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Sprenger,  F
Department Genetics, Max Planck Institute for Developmental Biology, Max Planck Society;

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Stevens,  LM
Department Genetics, Max Planck Institute for Developmental Biology, Max Planck Society;

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Nüsslein-Volhard,  C       
Department Genetics, Max Planck Institute for Developmental Biology, Max Planck Society;

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Citation

Sprenger, F., Stevens, L., & Nüsslein-Volhard, C. (1989). The Drosophila gene torso encodes a putative receptor tyrosine kinase. Nature, 338(6215), 478-483. doi:10.1038/338478a0.


Cite as: https://hdl.handle.net/21.11116/0000-000B-6B11-A
Abstract
The maternal gene torso, required for determination of anterior and posterior terminal structures in the Drosophila embryo, was cloned using P-element tagging. Genetic evidence suggests that the action of the gene product is spatially restricted to the terminal regions; the torso messenger RNA, however, is evenly distributed. Structural similarities of the predicted torso protein with growth-factor receptor tyrosine kinases suggest that the spatial restriction of torso activity results from a localized activation of the torso protein at the anterior and posterior egg pole.