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Meeting Abstract

Protein Sequence Analysis Using the MPI Bioinformatics Toolkit

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Alva,  V       
Department Protein Evolution, Max Planck Institute for Biology Tübingen, Max Planck Society;
Protein Bioinformatics Group, Department Protein Evolution, Max Planck Institute for Biology Tübingen, Max Planck Society;

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Citation

Alva, V. (2022). Protein Sequence Analysis Using the MPI Bioinformatics Toolkit. In 8th Alpbach Workshop: Coiled Coil, Fibrous and Repeat Proteins (pp. 9).


Cite as: https://hdl.handle.net/21.11116/0000-000B-6DEF-F
Abstract
The MPI Bioinformatics Toolkit (https://toolkit.tuebingen.mpg.de [1,2]) provides interactive access to a wide array of the best-performing bioinformatics tools and databases, including the state-of-the-

art protein sequence comparison methods HHblits and HHpred. In this talk, I will discuss the application of the Toolkit for detecting remote homologs, inferring protein function, and visualizing relationships in large sequence datasets. I will demonstrate these using, as an example, the coiled-coil segment-containing OmpM protein superfamily, whose members tether the outer membrane to the peptidoglycan layer in many Gram-negative bacteria [3].