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The MPI Bioinformatics Toolkit and its application to protein analysis and design

MPS-Authors
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Alva,  V       
Department Protein Evolution, Max Planck Institute for Developmental Biology, Max Planck Society;
Protein Bioinformatics Group, Department Protein Evolution, Max Planck Institute for Developmental Biology, Max Planck Society;

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Nam,  S-Z
Department Protein Evolution, Max Planck Institute for Developmental Biology, Max Planck Society;
Protein Bioinformatics Group, Department Protein Evolution, Max Planck Institute for Developmental Biology, Max Planck Society;

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Rau,  D
Department Protein Evolution, Max Planck Institute for Developmental Biology, Max Planck Society;
Protein Bioinformatics Group, Department Protein Evolution, Max Planck Institute for Developmental Biology, Max Planck Society;

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Stephens,  A
Department Protein Evolution, Max Planck Institute for Developmental Biology, Max Planck Society;
Protein Bioinformatics Group, Department Protein Evolution, Max Planck Institute for Developmental Biology, Max Planck Society;

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Kübler,  J
Department Protein Evolution, Max Planck Institute for Developmental Biology, Max Planck Society;

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Lozajic,  M
Department Protein Evolution, Max Planck Institute for Developmental Biology, Max Planck Society;

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Gabler,  F       
Department Protein Evolution, Max Planck Institute for Developmental Biology, Max Planck Society;
Protein Bioinformatics Group, Department Protein Evolution, Max Planck Institute for Developmental Biology, Max Planck Society;

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Lupas,  AN       
Department Protein Evolution, Max Planck Institute for Developmental Biology, Max Planck Society;

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Citation

Alva, V., Nam, S.-Z., Rau, D., Stephens, A., Kübler, J., Lozajic, M., et al. (2017). The MPI Bioinformatics Toolkit and its application to protein analysis and design. In 7th Alpbach Workshop: Coiled Coil, Fibrous and Repeat Proteins (pp. 5).


Cite as: https://hdl.handle.net/21.11116/0000-000B-6E27-F
Abstract
The MPI Bioinformatics Toolkit (https://toolkit.tuebingen.mpg.de) is an open and integrative Web service for advanced protein bioinformatic analysis. It includes a wide array of interconnected, state-of-the-art public and in-house tools, whose functionality ranges from the



identification of features such as coiled-coil segments (PCOILS, MARCOIL), internal sequence repeats (HHrepID, REPPER), and secondary structure (Quick2D) to the detection of remote homologs of known structure (HHpred) and subsequent generation of structural models (MODELLER). In fact, due to this breadth of its tools, our Toolkit has established itself as an important resource for experimental scientists and as a useful platform for teaching bioinformatic inquiry. Recently, we replaced the first version of the Toolkit, which was released in 2005 and had serviced over 2.5 million external queries, with an entirely new version built using modern Web technologies and with improved features for teaching and collaborative research. In the presentation, we will focus on the usefulness of the Toolkit for the analysis and design of proteins.