Fine-tuning of coiled coil design

Szczepaniak, K; Ludwiczak, J; Dunin-Horkawicz, S

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Fine-tuning of coiled coil design

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https://www.coiledcoils.net/download?name=Alpbach2017_program.pdf
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Citation

Szczepaniak, K., Ludwiczak, J., & Dunin-Horkawicz, S. (2017). Fine-tuning of coiled coil design. In 7th Alpbach Workshop: Coiled Coil, Fibrous and Repeat Proteins (pp. 18).

Cite as: https://hdl.handle.net/21.11116/0000-000B-6EE4-9

Abstract

Protein design is a procedure that aims at predicting sequences that will fold to a given backbone structure (target structure). Recent years have shown that computational design techniques can be used to create new coiled coils with well-defined topology. However, experimentally determined structures of designed coiled coils do not always perfectly match the assumed target structures. This raises the question whether these small discrepancies can be avoided or are they simply artefacts of structure determination or measurement procedures.