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Journal Article

Admixture has obscured signals of historical hard sweeps in humans

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Rohrlach,  Adam Ben       
Archaeogenetics, Max Planck Institute for the Science of Human History, Max Planck Society;

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Supplementary Methods, Text 1–6 and Figs. 1–21, and captions for Supplementary Tables 1–4 and Supplementary Data 1–114.
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Citation

Souilmi, Y., Tobler, R., Johar, A., Williams, M., Grey, S. T., Schmidt, J., et al. (2022). Admixture has obscured signals of historical hard sweeps in humans. Nature Ecology & Evolution, s41559-022-01914-9. doi:10.1038/s41559-022-01914-9.


Cite as: https://hdl.handle.net/21.11116/0000-000B-719A-8
Abstract
The role of natural selection in shaping biological diversity is an area of intense interest in modern biology. To date, studies of positive selection have primarily relied on genomic datasets from contemporary populations, which are susceptible to confounding factors associated with complex and often unknown aspects of population history. In particular, admixture between diverged populations can distort or hide prior selection events in modern genomes, though this process is not explicitly accounted for in most selection studies despite its apparent ubiquity in humans and other species. Through analyses of ancient and modern human genomes, we show that previously reported Holocene-era admixture has masked more than 50 historic hard sweeps in modern European genomes. Our results imply that this canonical mode of selection has probably been underappreciated in the evolutionary history of humans and suggest that our current understanding of the tempo and mode of selection in natural populations may be inaccurate.