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Journal Article

The charge carried by single‐channel currents of rat cultured muscle cells in the presence of local anaesthetics

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Neher,  Erwin       
Department of Membrane Biophysics, MPI for biophysical chemistry, Max Planck Society;

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Citation

Neher, E. (1983). The charge carried by single‐channel currents of rat cultured muscle cells in the presence of local anaesthetics. The Journal of Physiology, 339(1), 663-678. doi:10.1113/jphysiol.1983.sp014741.


Cite as: https://hdl.handle.net/21.11116/0000-000C-7565-F
Abstract
Acetylcholine-induced single-channel currents were measured in the presence of the lignocaine derivative QX222. Unit responses appeared as bursts of short current pulses as a result of the fast blocking action of the drug (QX222). The amplitude of the individual current pulses was not changed by the presence of the drug up to a concentration of 250 microM. The time integral of current during a burst, which for a sequential blocking model should be independent of drug concentration, decreased at concentrations of QX222 higher than 40 microM. The distribution of gap times within a burst could not be fitted by a single exponential for high concentrations of QX222. It is concluded that the simple sequential model of channel blockade does not apply for concentrations of QX222 higher than 40 microM.