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Inward current channels activated by intracellular Ca in cultured cardiac cells

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Neher,  Erwin       
Department of Membrane Biophysics, MPI for biophysical chemistry, Max Planck Society;

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Citation

Colquhoun, D., Neher, E., Reuter, H., & Stevens, C. (1981). Inward current channels activated by intracellular Ca in cultured cardiac cells. Nature, 294(5843), 752-754. doi:10.1038/294752a0.


Cite as: https://hdl.handle.net/21.11116/0000-000C-7545-3
Abstract
Present concepts of excitable membrane function are based primarily on knowledge of two classes of channels: those activated by neurotransmitters and those activated by membrane potential. Recent evidence suggests that these notions may have to be modified to include other channel types, such as special ion channels activated by membrane potential but regulated by ligands. We report here studies on single channel currents recorded from heart muscle cells, in which we have found a channel, abundant in cardiac membrane, which does not seem to belong in any of the familiar categories. This channel shows little selectivity between cations, but excludes anions. It is activated by intracellular Ca ions but is not appreciably affected by membrane potential.