Fluctuation and relaxation analysis of monazomycin-induced conductance in black 
lipid membranes

Moore, L.E.; Neher, Erwin

doi:10.1007/BF01869145

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Fluctuation and relaxation analysis of monazomycin-induced conductance in black lipid membranes

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Moore, L.E.
Abteilung Molekularer Systemaufbau, MPI for Biophysical Chemistry, Max Planck Society;

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Neher, Erwin
Department of Membrane Biophysics, MPI for biophysical chemistry, Max Planck Society;

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Citation

Moore, L., & Neher, E. (1976). Fluctuation and relaxation analysis of monazomycin-induced conductance in black lipid membranes. The Journal of Membrane Biology, 27(1), 347-362. doi:10.1007/BF01869145.

Cite as: https://hdl.handle.net/21.11116/0000-000B-762B-1

Abstract

Fluctuation and relaxation analyses were performed on monazomycin-induced conductance of lipid bilayer membranes. With both methods a slow (sec) and a fast (msec) current component are apparent; however, the amplitude of the slow, voltage-dependent process is greater than that of the fast component in the step relaxation experiment and less in the fluctuation experiment. The fluctuation analysis showed principally a rapid voltage-dependent process which appears to be related to the multistate character of the conducting channel. The experimental results are interpreted in terms of a simplified kinetic model which is used to calculate relaxation and noise amplitudes.