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Journal Article

Neuronal Ca2+ signalling takes the local route

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Neher,  Erwin       
Department of Membrane Biophysics, MPI for biophysical chemistry, Max Planck Society;

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Citation

Augustine, G., & Neher, E. (1992). Neuronal Ca2+ signalling takes the local route. Current Opinion in Neurobiology, 2(3), 302-307. doi:10.1016/0959-4388(92)90119-6.


Cite as: https://hdl.handle.net/21.11116/0000-000C-8CF4-3
Abstract
The past year has seen several sets of experimental results demonstrate that fast, large and highly localized rises in intracellular Ca2+ concentration can occur in neurons. These results confirm previous theoretical predictions of acute spatial compartmentalization of Ca2+ signalling, and document a form of signalling that may occur whenever rapid and local signal processing is the goal. The dimensions involved present severe challenges for attempts to directly measure these signalling events.